ESR 4.2
Novel tracers for the detection of bacterial infections

Project

Recent proof-of-principle studies have shown that fluorescently labeled antibiotics, such as vancomycin, can be applied to specifically target and detect bacterial infections. The objective of this project is to perform translational studies towards the clinical use of fluorescently or radioactively labeled antibiotics, metabolizable compounds, or other ligands as targeting molecules to specifically detect infections using ex vivo or in vivo model systems. The results will be applied to develop new generation diagnostics and immune-therapeutics. Specific requirements: background in biochemistry or molecular microbiology, and willingness to perform research with small laboratory animals.

Supervisors

Collaborations

The University of Edinburgh (UK)
The Institute for molecular Infection Biology of the University of Würzburg, Germany

Relevant publications

  1. van Oosten M, Hahn M, Crane LMA, Pleijhuis RG, Francis KP, van Dijl JM, et al. Targeted imaging of bacterial infections. FEMS Microbiol Rev. 2015 Nov;39(6):892–916.
  2. van Oosten M, Schäfer T, Gazendam JAC, Ohlsen K, Tsompanidou E, de Goffau MC, et al. Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin. Nat Commun. 2013 Oct 15;4.
  3. Heuker M, Gomes A, van Dijl JM, van Dam GM, Friedrich AW, Sinha B, et al. Preclinical studies and prospective clinical applications for bacteria-targeted imaging: the future is bright. Clin Transl Imaging [Internet]. 2016;1–12.

Keywords

infection, bacteria, imaging, tracer.