Invasive and biomaterial-associated staphylococcal infections in humans are often difficult to diagnose and treat. The objective of this project is to explore the application potential of several recently developed human monoclonal antibodies against pathogenic staphylococci to detect or fight infections precipitated by implanted materials. Antibodies will be labelled with near-infrared fluorophores, isotopes suitable for PET imaging, or photosensitive molecules suitable for photodynamic therapy and, subsequently, tested in animal infection models. The results will be applied to develop new generation diagnostics and immune-therapeutics. Specific requirements: background in biochemistry or molecular microbiology, and willingness to perform research with small laboratory animals.
UCB-Celltech (Slough, UK)
Institute for molecular Infection Biology of the University of Würzburg, Germany.
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monoclonal antibodies, Staphylococcus, infection.