ESR 4.1
Monoclonal antibodies to detect or fight staphylococcal infections

Project

Invasive and biomaterial-associated staphylococcal infections in humans are often difficult to diagnose and treat. The objective of this project is to explore the application potential of several recently developed human monoclonal antibodies against pathogenic staphylococci to detect or fight infections precipitated by implanted materials. Antibodies will be labelled with near-infrared fluorophores, isotopes suitable for PET imaging, or photosensitive molecules suitable for photodynamic therapy and, subsequently, tested in animal infection models. The results will be applied to develop new generation diagnostics and immune-therapeutics. Specific requirements: background in biochemistry or molecular microbiology, and willingness to perform research with small laboratory animals.

Supervisors

Collaborations

UCB-Celltech (Slough, UK)
Institute for molecular Infection Biology of the University of Würzburg, Germany.

Relevant publications

  1. van Oosten M, Hahn M, Crane LMA, Pleijhuis RG, Francis KP, van Dijl JM, et al. Targeted imaging of bacterial infections. FEMS Microbiol Rev. 2015 Nov;39(6):892–916.
  2. van Oosten M, Schäfer T, Gazendam JAC, Ohlsen K, Tsompanidou E, de Goffau MC, et al. Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin. Nat Commun. 2013 Oct 15;4.
  3. Heuker M, Gomes A, van Dijl JM, van Dam GM, Friedrich AW, Sinha B, et al. Preclinical studies and prospective clinical applications for bacteria-targeted imaging: the future is bright. Clin Transl Imaging [Internet]. 2016;1–12.

Keywords

monoclonal antibodies, Staphylococcus, infection.