Prophylaxis is often prescribed to prevent infections in immuno-compromised patients. However, antimicrobial drugs used for prophylaxis are often prescribed in a one size fits all strategy, which may lead to break through infections or adverse drug effects. The PhD student will be supervised by the experts who successfully raised awareness of this problem. Training will address adequate dosing of the most important antimicrobial drugs used for prophylaxis in immuno-compromised patients: valganciclovir, co-trimoxazole and ciprofloxacin, fluconazole, posaconazole and voriconazole. You will evaluate current practice and develop a dosing algorithm for optimized administration of antimicrobial drugs for prophylaxis. Pharmacokinetic modeling to support the dose algorithm will be followed at the University of Liverpool under supervision of prof William Hope. In addition, cost effectiveness of different dosing strategies will be calculated. An internship at MSD on pharmaco-vigilance and medical information for healthcare professionals will be an integral part of the PhD training.
- Dr. JWC Alffenaar, hospital pharmacist – clinical pharmacologist » Link
- Prof. dr. TS van der Werf, chest physician – infectious diseases expert » Link
University of Liverpool, UK
MSD, The Netherlands
Immuno-compromised patients, prophylaxis, individualized dosing